Hey man, just read through everything that's been written here and owning the Painkiller I'll tell you, don't dismiss it, especially not if you're considering it for a Mahogany guitar!
I have a PK Bridge and CS Neck combo in my 93 Jackson Fusion ("Fusion" describing the mix between a Jackson and a Gibson, it has a Mahogany Body and the shorter 24.75 inch scale) and those pickups sound fantastic in it. It's not all Mahogany, the Neck is made out of Maple with a Rosewood fretboard, still the guitar sounds naturally very full with lots of depth and body to the sound. The Painkiller just evens out the frequencies perfectly, having a big but tight and defined bottom end, punchy, clear and articulate mids with the right amount of highs, never sounding "ice picky" as some people judge it to be. I think it really depends on the scale and the wood, and for the Gibson Scale and Mahogany I'm pretty sure you will love it. I even could have put an Emerald or Rebel Yell into the guitar (which are said to be the brightest BKPs) and it still wouldn't be over the top, you could consider those pickups as well (as long as you have enough gain from your amp to fully saturate them). Regarding the sound, it always very responsive to your playing, clear as a tear, defined and translates the character of the guitar. The Coldsweat stays on pair with the Painkiller amazingly well and gives you great cleans with amazing fluid leads especially well suited to sweep picking. Hope that helps.
Cheers!