The only band I know that uses a 6534+ is The Devil Wears Prada, and the guy still uses a tubescreamer on top. Has this pre-gain pretty high, on 5.5 as well.
Some people say the 6505+ is a middy amp, some don't, I would't say it has as many as a Marshall, for example.
I've modded my head so the lead channel is quiet, so I don't need to mess about with FX loops and stuff, saving set up time. Only noise I have to worry about now is the tubescreamer making noise once kicked on. I have this under control though with the loop of the ISP.
If using an EQ what am I looking to boost the most?